Context and Menarini Entered into a Clinical Trial Collaboration and Supply Agreement to Evaluate ONA-XR + Elacestrant for Metastatic Breast Cancer
Shots:
- The companies collaborated to initiate P-Ib/II (ELONA) clinical PoC trial evaluating onapristone extended-release (ONA-XR) + elacestrant in patients with ER+, PR+ HER2- mBC who have prior been treated with a CDK4/6 inhibitor
- The trial is expected to be initiated in Q4’22. Additionally, Context will be responsible to sponsor the clinical trial and Menarini will supply elacestrant at no cost
- In a P-III trial, Elacestrant showed an improvement in PFS over SoC endocrine therapy in patients with ER+, HER2- mBC with a 30% reduction in risk of progression or death in all patients, 22% vs 9% of patients were alive and progression-free @12mos. after elacestrant treatment initiation in the overall population
Ref: GlobeNewswire | Image: Context Therapeutics
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